Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors

Ubiquitin specific peptidase 28 (USP28) is closely associated to the occurrence and development of various malignancies, and thus has been validated as a promising therapeutic target for cancer therapy. To date, only few USP28 inhibitors with moderate inhibitory activity have been reported, highly p...

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Detalles Bibliográficos
Autores principales: Liu, Zhenzhen, Zhao, Taoqian, Li, Zhonghua, Sun, Kai, Fu, Yundong, Cheng, Ting, Guo, Jimin, Yu, Bin, Shi, Xiaojing, Liu, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://www.ncbi.nlm.nih.gov/pubmed/32963944
http://dx.doi.org/10.1016/j.apsb.2019.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488365/
https://www.ncbi.nlm.nih.gov/pubmed/32963944
http://dx.doi.org/10.1016/j.apsb.2019.12.008

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