Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

To provide a comprehensive mechanistic interpretation of how known trait-associated SNPs affect complex traits, we propose a method, Primo, for integrative analysis of GWAS summary statistics with multiple sets of omics QTL summary statistics from different cellular conditions or studies. Primo exam...

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Detalles Bibliográficos
Autores principales: Gleason, Kevin J., Yang, Fan, Pierce, Brandon L., He, Xin, Chen, Lin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488447/
https://www.ncbi.nlm.nih.gov/pubmed/32912334
http://dx.doi.org/10.1186/s13059-020-02125-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488447/
https://www.ncbi.nlm.nih.gov/pubmed/32912334
http://dx.doi.org/10.1186/s13059-020-02125-w

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