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1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function

BACKGROUND: The indoleamine 2, 3-dioxygenase (IDO) inhibitor 1-methyl-tryptophan (1-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors by inhibiting tumor immune escape. A greater understanding of IDO activity is required to begin to understand the mo...

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Detalles Bibliográficos
Autores principales: Ma, Huihan, Qin, Qian, Mi, Jiaqing, Feng, Qinmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488546/
https://www.ncbi.nlm.nih.gov/pubmed/32912307
http://dx.doi.org/10.1186/s40360-020-00439-w