PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis

We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQ...

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Detalles Bibliográficos
Autores principales: Zhang, Yuhua, Quick, Corbin, Yu, Ketian, Barbeira, Alvaro, Luca, Francesca, Pique-Regi, Roger, Kyung Im, Hae, Wen, Xiaoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488550/
https://www.ncbi.nlm.nih.gov/pubmed/32912253
http://dx.doi.org/10.1186/s13059-020-02026-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488550/
https://www.ncbi.nlm.nih.gov/pubmed/32912253
http://dx.doi.org/10.1186/s13059-020-02026-y

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