Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice

Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human superoxide dismutase 1 (hSOD1) that a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lehmann, Manuela, Marklund, Matthew, Bolender, Anna-Lena, Bidhendi, Elaheh E., Zetterström, Per, Andersen, Peter M., Brännström, Thomas, Marklund, Stefan L., Gilthorpe, Jonathan D., Nordström, Ulrika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://www.ncbi.nlm.nih.gov/pubmed/32928301
http://dx.doi.org/10.1186/s40478-020-01032-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488686/
https://www.ncbi.nlm.nih.gov/pubmed/32928301
http://dx.doi.org/10.1186/s40478-020-01032-2

Ejemplares similares