From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

BACKGROUND: Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS: We systematically analyzed the smoking-related DNA methyl...

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Detalles Bibliográficos
Autores principales: Chen, Zhishan, Wen, Wanqing, Cai, Qiuyin, Long, Jirong, Wang, Ying, Lin, Weiqiang, Shu, Xiao-ou, Zheng, Wei, Guo, Xingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488848/
https://www.ncbi.nlm.nih.gov/pubmed/32928150
http://dx.doi.org/10.1186/s12885-020-07368-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488848/
https://www.ncbi.nlm.nih.gov/pubmed/32928150
http://dx.doi.org/10.1186/s12885-020-07368-1

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