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From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes
BACKGROUND: Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS: We systematically analyzed the smoking-related DNA methyl...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488848/ https://www.ncbi.nlm.nih.gov/pubmed/32928150 http://dx.doi.org/10.1186/s12885-020-07368-1 |