A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

Glutamate toxicity is a pathomechanism that contributes to neuronal cell death in a wide range of acute and chronic neurodegenerative and neuroinflammatory diseases. Activation of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and breakdown of the mitochondrial membrane potential are key ev...

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Detalles Bibliográficos
Autores principales: Merz, Simon F., Bengtson, C. Peter, Tepohl, Clara, Hagenston, Anna M., Bading, Hilmar, Bas-Orth, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489219/
https://www.ncbi.nlm.nih.gov/pubmed/32928261
http://dx.doi.org/10.1186/s13041-020-00641-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489219/
https://www.ncbi.nlm.nih.gov/pubmed/32928261
http://dx.doi.org/10.1186/s13041-020-00641-1

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