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A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

Glutamate toxicity is a pathomechanism that contributes to neuronal cell death in a wide range of acute and chronic neurodegenerative and neuroinflammatory diseases. Activation of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and breakdown of the mitochondrial membrane potential are key ev...

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Detalles Bibliográficos
Autores principales:	Merz, Simon F., Bengtson, C. Peter, Tepohl, Clara, Hagenston, Anna M., Bading, Hilmar, Bas-Orth, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489219/ https://www.ncbi.nlm.nih.gov/pubmed/32928261 http://dx.doi.org/10.1186/s13041-020-00641-1

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