Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN

Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, JAK2, CALR, and MPL lead to constitutively active JAK-STAT signaling. Common clinical featu...

Descripción completa

Detalles Bibliográficos
Autores principales: Jutzi, Jonas Samuel, Mullally, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489333/
https://www.ncbi.nlm.nih.gov/pubmed/32983162
http://dx.doi.org/10.3389/fimmu.2020.02093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489333/
https://www.ncbi.nlm.nih.gov/pubmed/32983162
http://dx.doi.org/10.3389/fimmu.2020.02093

Ejemplares similares