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Puromycin reactivity does not accurately localize translation at the subcellular level

Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains from translating ribosomes. Puromycin has been used in molecular biology research for decades as a translation inhibitor. The development of puromycin antibodies and derivatized puromyci...

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Detalles Bibliográficos
Autores principales: Enam, Syed Usman, Zinshteyn, Boris, Goldman, Daniel H, Cassani, Madeline, Livingston, Nathan M, Seydoux, Geraldine, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490009/
https://www.ncbi.nlm.nih.gov/pubmed/32844748
http://dx.doi.org/10.7554/eLife.60303