Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress

BACKGROUND: Oxidative stress induced by chronic hyperglycemia is recognized as a significant mechanistic contributor to the development of diabetic kidney disease (DKD). Nonphagocytic nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in m...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Jun Mo, Lee, Hyun-Seob, Kim, Junghyun, Yang, Dong Ho, Jeong, Hye Yun, Lee, Yu Ho, Kim, Dong-Jin, Park, Seon Hwa, Sung, MinJi, Kim, Jaehee, An, Hyun-Ju, Lee, Sang Ho, Lee, So-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490204/
https://www.ncbi.nlm.nih.gov/pubmed/32924342
http://dx.doi.org/10.3346/jkms.2020.35.e305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490204/
https://www.ncbi.nlm.nih.gov/pubmed/32924342
http://dx.doi.org/10.3346/jkms.2020.35.e305

Ejemplares similares