Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration

PURPOSE: To determine whether caveolin-1 (i) prevents epithelial–mesenchymal transition in the RPE and laser-induced subretinal fibrosis and (ii) promotes or inhibits cellular senescence in the RPE. METHODS: We examined laser-induced subretinal fibrosis and RPE cell contraction in wild-type and Cave...

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Detalles Bibliográficos
Autores principales: Shimizu, Hideyuki, Yamada, Kazuhisa, Suzumura, Ayana, Kataoka, Keiko, Takayama, Kei, Sugimoto, Masataka, Terasaki, Hiroko, Kaneko, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490224/
https://www.ncbi.nlm.nih.gov/pubmed/32926104
http://dx.doi.org/10.1167/iovs.61.11.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490224/
https://www.ncbi.nlm.nih.gov/pubmed/32926104
http://dx.doi.org/10.1167/iovs.61.11.21

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