Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

Thalidomide and its derivatives exert not only therapeutic effects as immunomodulatory drugs (IMiDs) but also adverse effects such as teratogenicity, which are due in part to different C2H2 zinc-finger (ZF) transcription factors, IKZF1 (or IKZF3) and SALL4, respectively. Here, we report the structur...

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Detalles Bibliográficos
Autores principales: Furihata, Hirotake, Yamanaka, Satoshi, Honda, Toshiaki, Miyauchi, Yumiko, Asano, Atsuko, Shibata, Norio, Tanokura, Masaru, Sawasaki, Tatsuya, Miyakawa, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490372/
https://www.ncbi.nlm.nih.gov/pubmed/32929090
http://dx.doi.org/10.1038/s41467-020-18488-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490372/
https://www.ncbi.nlm.nih.gov/pubmed/32929090
http://dx.doi.org/10.1038/s41467-020-18488-4

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