Cargando…

Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism

Theaflavin (TF) is a major active pigment and polyphenol of tea, possessing anti-cancer activities. However, little is known about its activity and mechanism on melanoma cells. To fill this gap, we conducted in vitro experiments (cell viability assay, morphology observation, DAPI staining, and flow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lei, Yan, Bo, Meng, Shijie, Zhou, Li, Xu, Yiqiao, Du, Wenxi, Shan, Letian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490558/ https://www.ncbi.nlm.nih.gov/pubmed/32982737 http://dx.doi.org/10.3389/fphar.2020.01317

Ejemplares similares

Anti-Proliferative, Pro-Apoptotic, Anti-Migrative and Tumor-Inhibitory Effects and Pleiotropic Mechanism of Theaflavin on B16F10 Melanoma Cells
por: Zhang, Lei, et al.
Publicado: (2021)

Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor
por: Cui, Xiangling, et al.
Publicado: (2020)

The Tubulin Inhibitor VERU-111 in Combination With Vemurafenib Provides an Effective Treatment of Vemurafenib-Resistant A375 Melanoma
por: Cui, Hongmei, et al.
Publicado: (2021)

Novel Anti-Melanoma Compounds Are Efficacious in A375 Cell Line Xenograft Melanoma Model in Nude Mice
por: Velayutham, Sadeeshkumar, et al.
Publicado: (2023)

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos
por: Xia, Qing, et al.
Publicado: (2021)

Theaflavin-3, 3′-Digallate Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Ovariectomy-Induced Bone Loss in Mice
por: Ai, Zexin, et al.
Publicado: (2020)

Green tea-derived theabrownin induces cellular senescence and apoptosis of hepatocellular carcinoma through p53 signaling activation and bypassed JNK signaling suppression
por: Xu, Jiaan, et al.
Publicado: (2022)

Theaflavin promoted apoptosis in nasopharyngeal carcinoma unexpectedly via inducing autophagy in vitro
por: Xu, Jing, et al.
Publicado: (2022)

Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway
por: Niu, Ting, et al.
Publicado: (2023)

SGLT1 Inhibition Attenuates Apoptosis in Diabetic Cardiomyopathy via the JNK and p38 Pathway
por: Lin, Na, et al.
Publicado: (2021)

Theaflavin-3,3′-Digallate Promotes the Formation of Osteoblasts Under Inflammatory Environment and Increases the Bone Mass of Ovariectomized Mice
por: Ge, Gaoran, et al.
Publicado: (2021)

The Induction of Apoptosis in A375 Malignant Melanoma Cells by Sutherlandia frutescens
por: van der Walt, Nicola B., et al.
Publicado: (2016)

Synthesis of Theaflavins and Their Functions
por: Takemoto, Masumi, et al.
Publicado: (2018)

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats
por: Yan, Bo, et al.
Publicado: (2018)

Theaflavin Chemistry and Its Health Benefits
por: Shan, Zhiguo, et al.
Publicado: (2021)

Nanofat lysate ameliorates pain and cartilage degradation of osteoarthritis through activation of TGF-β–Smad2/3 signaling of chondrocytes
por: Ge, Yanzhi, et al.
Publicado: (2023)

Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro
por: Chang, Chin-Kuo, et al.
Publicado: (2022)

Effects of ginsenoside Rg3 on apoptosis in A375.S2 melanoma cells
por: Kim, Joo Hyoung, et al.
Publicado: (2019)

Corrigendum: Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro
por: Chang, Chin-Kuo, et al.
Publicado: (2022)

Anti-Proliferative and Apoptosis-Inducing Effect of Theabrownin against Non-small Cell Lung Adenocarcinoma A549 Cells
por: Wu, Feifei, et al.
Publicado: (2016)

Theaflavin-3,3′-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells
por: Wu, Yichen, et al.
Publicado: (2022)

Anti-Cancer Properties of Theaflavins
por: O’Neill, Eric J., et al.
Publicado: (2021)

A single-dose, randomized, open-labeled, parallel-group study comparing the pharmacokinetics, pharmacodynamics and safety of leuprolide acetate microspheres 3.75 mg and Enantone(®) 3.75 mg in healthy male subjects
por: Hu, Xingjiang, et al.
Publicado: (2022)

New withanolides from Physalis minima and their cytotoxicity against A375 human melanoma cells
por: Zhang, Meng, et al.
Publicado: (2020)

Zanthoxylum bungeanum seed oil inhibits tumorigenesis of human melanoma A375 by regulating CDC25A/CyclinB1/CDK1 signaling pathways in vitro and in vivo
por: Wang, Wanting, et al.
Publicado: (2023)

Compound Dihuang Granule Inhibits Nigrostriatal Pathway Apoptosis in Parkinson’s Disease by Suppressing the JNK/AP-1 Pathway
por: Wang, Li, et al.
Publicado: (2021)

Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts
por: He, Tao, et al.
Publicado: (2022)

ROS/JNK/C-Jun Pathway is Involved in Chaetocin Induced Colorectal Cancer Cells Apoptosis and Macrophage Phagocytosis Enhancement
por: Wang, Huihui, et al.
Publicado: (2021)

The Effect of Theaflavins on the Gut Microbiome and Metabolites in Diabetic Mice
por: Wang, Jun, et al.
Publicado: (2023)

Oleanolic acid induces p53-dependent apoptosis via the ERK/JNK/AKT pathway in cancer cell lines in prostatic cancer xenografts in mice
por: Kim, Gyeong-Ji, et al.
Publicado: (2018)

Synergistic Apoptosis-Inducing Effects on A375 Human Melanoma Cells of Natural Borneol and Curcumin
por: Chen, Jianping, et al.
Publicado: (2014)

Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells
por: Si, Lingling, et al.
Publicado: (2018)

Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells
por: Liu, Wenjing, et al.
Publicado: (2019)

Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis
por: Zhang, Lei, et al.
Publicado: (2020)

The roles of theaflavins in reducing dentin erosion
por: Guo, Jing, et al.
Publicado: (2023)

The Inhibitory Effect of Polyphenon 60 from Green Tea on Melanin and Tyrosinase in Zebrafish and A375 Human Melanoma Cells
por: Kazi, Mehar Ali, et al.
Publicado: (2022)

Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model
por: Hubmann, Rainer, et al.
Publicado: (2017)

Effect of theaflavin-3,3′-digallate on leptin-deficient induced nonalcoholic fatty liver disease might be related to lipid metabolism regulated by the Fads1/PPARδ/Fabp4 axis and gut microbiota
por: Zhou, Cheng, et al.
Publicado: (2022)

Norcantharidin Induces Human Melanoma A375-S2 Cell Apoptosis through Mitochondrial and Caspase Pathways
por: An, Wei-wei, et al.
Publicado: (2004)

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM
por: Woo, Joong-Seok, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v00iheev2pn796tdlems8mbhgt