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Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity

Vascular dysfunctions such as vascular hyporeactivity following ischemic/hypoxic injury are a major cause of death in injured patients. In this study, we showed that treatment with mitochondrial division inhibitor 1 (Mdivi-1), a selective inhibitor of dynamin-related protein 1 (Drp1), significantly...

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Detalles Bibliográficos
Autores principales: Duan, Chenyang, Wang, Li, Zhang, Jie, Xiang, Xinming, Wu, Yue, Zhang, Zisen, Li, Qinghui, Tian, Kunlun, Xue, Mingying, Liu, Liangming, Li, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490562/
https://www.ncbi.nlm.nih.gov/pubmed/32911435
http://dx.doi.org/10.1016/j.redox.2020.101706