Cargando…

The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies

Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic instability, which is driven by GTP hydrolysis. Structures of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knossow, Marcel, Campanacci, Valérie, Khodja, Liza Ammar, Gigant, Benoît
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491153/ https://www.ncbi.nlm.nih.gov/pubmed/32920486 http://dx.doi.org/10.1016/j.isci.2020.101511

Ejemplares similares

Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors
por: Campanacci, Valérie, et al.
Publicado: (2022)

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
por: Wang, Weiyi, et al.
Publicado: (2017)

Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin
por: Ahmad, Shoeb, et al.
Publicado: (2016)

Selection and Characterization of Artificial Proteins Targeting the Tubulin α Subunit
por: Campanacci, Valérie, et al.
Publicado: (2019)

GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation
por: Ayukawa, Rie, et al.
Publicado: (2021)

Simulations of Tubulin Sheet Polymers as Possible Structural Intermediates in Microtubule Assembly
por: Wu, Zhanghan, et al.
Publicado: (2009)

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure
por: Howes, Stuart C., et al.
Publicado: (2014)

Tubulin but not microtubule
por: Dove, Alan W.
Publicado: (2002)

Reassembly of flagellar B (alpha beta) tubulin into singlet microtubules: consequences for cytoplasmic microtubule structure and assembly
Publicado: (1981)

YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules
por: Chernov, Konstantin G, et al.
Publicado: (2008)

Mechanical properties of brain tubulin and microtubules
Publicado: (1988)

Structural insights into the mechanism of GTP initiation of microtubule assembly
por: Zhou, Ju, et al.
Publicado: (2023)

The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability
por: Manka, Szymon W., et al.
Publicado: (2018)

Cell cycle regulation of tubulin RNA level, tubulin protein synthesis, and assembly of microtubules in Physarum
Publicado: (1984)

The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules
Publicado: (1986)

Functional role of ɛ-tubulin in the assembly of the centriolar microtubule scaffold
por: Dupuis-Williams, Pascale, et al.
Publicado: (2002)

Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells
Publicado: (1995)

The contribution of αβ-tubulin curvature to microtubule dynamics
por: Brouhard, Gary J., et al.
Publicado: (2014)

Tubulin Post-Translational Modifications and Microtubule Dynamics
por: Wloga, Dorota, et al.
Publicado: (2017)

Copolymerization of two distinct tubulin isotypes during microtubule assembly in vitro
Publicado: (1990)

Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells
Publicado: (1981)

Microtubule dynamics at low temperature: evidence that tubulin recycling limits assembly
por: Li, Gabriella, et al.
Publicado: (2020)

Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes
Publicado: (1985)

A microtubule bestiary: structural diversity in tubulin polymers
por: Chaaban, Sami, et al.
Publicado: (2017)

Effects of α-tubulin acetylation on microtubule structure and stability
por: Eshun-Wilson, Lisa, et al.
Publicado: (2019)

Microtubule nucleation by γ-tubulin complexes and beyond
por: Tovey, Corinne A., et al.
Publicado: (2018)

Mechanism of microtubule stabilization by taccalonolide AJ
por: Wang, Yuxi, et al.
Publicado: (2017)

Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays
por: Nithianantham, Stanley, et al.
Publicado: (2018)

A Comprehensive Study on the Electrostatic Properties of Tubulin-Tubulin Complexes in Microtubules
por: Guo, Wenhan, et al.
Publicado: (2023)

Microtubule assembly governed by tubulin allosteric gain in flexibility and lattice induced fit
por: Igaev, Maxim, et al.
Publicado: (2018)

c-Abl kinase-mediated phosphorylation of γ-tubulin promotes γ-tubulin ring complexes assembly and microtubule nucleation
por: Wang, Guang-Fei, et al.
Publicado: (2022)

Efficient formation of bipolar microtubule bundles requires microtubule-bound γ-tubulin complexes
por: Janson, Marcel E., et al.
Publicado: (2005)

Cytoplasmic microtubule assembly-disassembly from endogenous tubulin in a Brij-lysed cell model
Publicado: (1983)

Human chromosomes and centrioles as nucleating sites for the in vitro assembly of microtubules from bovine brain tubulin
Publicado: (1975)

Structure and dynamics of Odinarchaeota tubulin and the implications for eukaryotic microtubule evolution
por: Akıl, Caner, et al.
Publicado: (2022)

New insights into the mechanochemical coupling mechanism of kinesin–microtubule complexes from their high-resolution structures
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2023)

Specialist α-tubulins for pluralist microtubules
por: Moore, Jeffrey K., et al.
Publicado: (2021)

Tubulin/microtubules as novel clozapine targets
por: Hino, Mizuki, et al.
Publicado: (2021)

γ-Tubulin in microtubule nucleation and beyond
por: Sulimenko, Vadym, et al.
Publicado: (2022)

Thermal hysteresis in microtubule assembly/disassembly dynamics: The aging-induced degradation of tubulin dimers
por: Wu, R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s943cj3e07ak2dsukune2o5d07