A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway

A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune response via activation of NF-κB and IRF3. Nevertheless,...

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Detalles Bibliográficos
Autores principales: Zablocki-Thomas, Laurent, Menzies, Sam A, Lehner, Paul J, Manel, Nicolas, Benaroch, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491238/
https://www.ncbi.nlm.nih.gov/pubmed/32248720
http://dx.doi.org/10.1177/1753425920915507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491238/
https://www.ncbi.nlm.nih.gov/pubmed/32248720
http://dx.doi.org/10.1177/1753425920915507

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