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A genome-wide CRISPR screen identifies regulation factors of the TLR3 signalling pathway

A subset of TLRs is specialised in the detection of incoming pathogens by sampling endosomes for nucleic acid contents. Among them, TLR3 senses the abnormal presence of double-stranded RNA in the endosomes and initiates a potent innate immune response via activation of NF-κB and IRF3. Nevertheless,...

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Detalles Bibliográficos
Autores principales:	Zablocki-Thomas, Laurent, Menzies, Sam A, Lehner, Paul J, Manel, Nicolas, Benaroch, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491238/ https://www.ncbi.nlm.nih.gov/pubmed/32248720 http://dx.doi.org/10.1177/1753425920915507

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