Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer

Long-term estrogen deprivation (LTED) with tamoxifen (TAM) or aromatase inhibitors leads to endocrine-resistance, whereby physiologic levels of estrogen kill breast cancer (BC). Estrogen therapy is effective in treating patients with advanced BC after resistance to TAM and aromatase inhibitors devel...

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Detalles Bibliográficos
Autores principales: Abderrahman, Balkees, Maximov, Philipp Y., Curpan, Ramona F., Hanspal, Jay S., Fan, Ping, Xiong, Rui, Tonetti, Debra A., Thatcher, Gregory R.J., Jordan, V. Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491312/
https://www.ncbi.nlm.nih.gov/pubmed/32788222
http://dx.doi.org/10.1124/molpharm.120.000054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491312/
https://www.ncbi.nlm.nih.gov/pubmed/32788222
http://dx.doi.org/10.1124/molpharm.120.000054

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