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Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination

Fission yeast Erh1 exists in a complex with RNA-binding protein Mmi1. Deletion of erh1 up-regulates the phosphate homeostasis gene pho1, which is normally repressed by transcription in cis of a 5′ flanking prt lncRNA. Here we present evidence that de-repression of pho1 by erh1Δ is achieved through p...

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Detalles Bibliográficos
Autores principales: Schwer, Beate, Sanchez, Ana M., Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491324/
https://www.ncbi.nlm.nih.gov/pubmed/32546512
http://dx.doi.org/10.1261/rna.076463.120