Elimination of Calm1 long 3′-UTR mRNA isoform by CRISPR–Cas9 gene editing impairs dorsal root ganglion development and hippocampal neuron activation in mice

The majority of mouse and human genes are subject to alternative cleavage and polyadenylation (APA), which most often leads to the expression of two or more alternative length 3′ untranslated region (3′-UTR) mRNA isoforms. In neural tissues, there is enhanced expression of APA isoforms with longer 3...

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Detalles Bibliográficos
Autores principales: Bae, Bongmin, Gruner, Hannah N., Lynch, Maebh, Feng, Ting, So, Kevin, Oliver, Daniel, Mastick, Grant S., Yan, Wei, Pieraut, Simon, Miura, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491327/
https://www.ncbi.nlm.nih.gov/pubmed/32522888
http://dx.doi.org/10.1261/rna.076430.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491327/
https://www.ncbi.nlm.nih.gov/pubmed/32522888
http://dx.doi.org/10.1261/rna.076430.120

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