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Frame-shifted proteins of a given gene are unlikely to retain the same function

In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed.

Detalles Bibliográficos
Autor principal: Mankin, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491333/
https://www.ncbi.nlm.nih.gov/pubmed/32503919
http://dx.doi.org/10.1261/rna.076398.120