Frame-shifted proteins of a given gene are unlikely to retain the same function

In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed.

Detalles Bibliográficos
Autor principal: Mankin, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491333/
https://www.ncbi.nlm.nih.gov/pubmed/32503919
http://dx.doi.org/10.1261/rna.076398.120
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author Mankin, Alexander S.
author_facet Mankin, Alexander S.
author_sort Mankin, Alexander S.
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description In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed.
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spelling pubmed-74913332020-10-01 Frame-shifted proteins of a given gene are unlikely to retain the same function Mankin, Alexander S. RNA Letter to the Editor In a recently published paper, Huang and coworkers claim that proteins translated in different reading frames from the same mRNA can have similar functions. This conclusion is possibly incorrect due to the possibility that the wild-type protein could still be expressed. Cold Spring Harbor Laboratory Press 2020-10 /pmc/articles/PMC7491333/ /pubmed/32503919 http://dx.doi.org/10.1261/rna.076398.120 Text en © 2020 Mankin; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article, published in RNA, is available undera Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Letter to the Editor
Mankin, Alexander S.
Frame-shifted proteins of a given gene are unlikely to retain the same function
title Frame-shifted proteins of a given gene are unlikely to retain the same function
title_full Frame-shifted proteins of a given gene are unlikely to retain the same function
title_fullStr Frame-shifted proteins of a given gene are unlikely to retain the same function
title_full_unstemmed Frame-shifted proteins of a given gene are unlikely to retain the same function
title_short Frame-shifted proteins of a given gene are unlikely to retain the same function
title_sort frame-shifted proteins of a given gene are unlikely to retain the same function
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491333/
https://www.ncbi.nlm.nih.gov/pubmed/32503919
http://dx.doi.org/10.1261/rna.076398.120
work_keys_str_mv AT mankinalexanders frameshiftedproteinsofagivengeneareunlikelytoretainthesamefunction

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