Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

Human neutrophil elastase (HNE) is involved in a number of essential physiological processes and has been identified as a potential therapeutic target for treating acute and chronic lung injury. Nevertheless, only one drug, Sivelestat, has been approved for clinical use and just in Japan and the Rep...

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Detalles Bibliográficos
Autores principales: Crocetti, Letizia, Giovannoni, Maria Paola, Cantini, Niccolò, Guerrini, Gabriella, Vergelli, Claudia, Schepetkin, Igor A., Khlebnikov, Andrei I., Quinn, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491426/
https://www.ncbi.nlm.nih.gov/pubmed/33033716
http://dx.doi.org/10.3389/fchem.2020.00795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491426/
https://www.ncbi.nlm.nih.gov/pubmed/33033716
http://dx.doi.org/10.3389/fchem.2020.00795

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