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Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors
Human neutrophil elastase (HNE) is involved in a number of essential physiological processes and has been identified as a potential therapeutic target for treating acute and chronic lung injury. Nevertheless, only one drug, Sivelestat, has been approved for clinical use and just in Japan and the Rep...
Autores principales: | Crocetti, Letizia, Giovannoni, Maria Paola, Cantini, Niccolò, Guerrini, Gabriella, Vergelli, Claudia, Schepetkin, Igor A., Khlebnikov, Andrei I., Quinn, Mark T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491426/ https://www.ncbi.nlm.nih.gov/pubmed/33033716 http://dx.doi.org/10.3389/fchem.2020.00795 |
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