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Whole genome sequencing for the investigation of canine mammary tumor inheritance - an initial assessment of high-risk breast cancer genes reveal BRCA2 and STK11 variants potentially associated with risk in purebred dogs

BACKGROUND: Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an increased risk of certain cancers. To our knowledge, there have been no published r...

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Detalles Bibliográficos
Autores principales: Huskey, Anna L. W., Goebel, Katie, Lloveras-Fuentes, Carlos, McNeely, Isaac, Merner, Nancy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491476/
http://dx.doi.org/10.1186/s40575-020-00084-w