SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcript...

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Detalles Bibliográficos
Autores principales: Pérez-Bermejo, Juan A., Kang, Serah, Rockwood, Sarah J., Simoneau, Camille R., Joy, David A., Ramadoss, Gokul N., Silva, Ana C., Flanigan, Will R., Li, Huihui, Nakamura, Ken, Whitman, Jeffrey D., Ott, Melanie, Conklin, Bruce R., McDevitt, Todd C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491510/
https://www.ncbi.nlm.nih.gov/pubmed/32935097
http://dx.doi.org/10.1101/2020.08.25.265561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491510/
https://www.ncbi.nlm.nih.gov/pubmed/32935097
http://dx.doi.org/10.1101/2020.08.25.265561

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