Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

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The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human...

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Detalles Bibliográficos
Autores principales: Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas P., Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James B., Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya V., Shen, Kuang, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492024/
https://www.ncbi.nlm.nih.gov/pubmed/32991842
http://dx.doi.org/10.1016/j.cell.2020.09.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492024/
https://www.ncbi.nlm.nih.gov/pubmed/32991842
http://dx.doi.org/10.1016/j.cell.2020.09.032

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