Deep sequencing shows that accumulation of potentially pathogenic mtDNA mutations rather than mtDNA copy numbers may be associated with early embryonic loss

PURPOSE: To explore the relationship between mitochondrial DNA quantity and heteroplasmy and early embryonic loss. METHODS: A total of 150 villous samples from patients with spontaneous abortion (SA, n = 75) or induced abortion (IA, n = 75) were collected. qPCR and next-generation sequencing (NGS) w...

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Detalles Bibliográficos
Autores principales: Ji, Licheng, Liao, Tingting, Yang, Juan, Su, Houming, Song, Jianyuan, Qian, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492355/
https://www.ncbi.nlm.nih.gov/pubmed/32700162
http://dx.doi.org/10.1007/s10815-020-01893-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492355/
https://www.ncbi.nlm.nih.gov/pubmed/32700162
http://dx.doi.org/10.1007/s10815-020-01893-5

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