Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis. Importantly, the aggregate-membrane interaction that drives f...

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Detalles Bibliográficos
Autores principales: Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492459/
https://www.ncbi.nlm.nih.gov/pubmed/32341450
http://dx.doi.org/10.1038/s41418-020-0542-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492459/
https://www.ncbi.nlm.nih.gov/pubmed/32341450
http://dx.doi.org/10.1038/s41418-020-0542-z

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