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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis. Importantly, the aggregate-membrane interaction that drives f...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492459/ https://www.ncbi.nlm.nih.gov/pubmed/32341450 http://dx.doi.org/10.1038/s41418-020-0542-z |