Cargando…

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis. Importantly, the aggregate-membrane interaction that drives f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492459/ https://www.ncbi.nlm.nih.gov/pubmed/32341450 http://dx.doi.org/10.1038/s41418-020-0542-z

Ejemplares similares

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
por: Ludtmann, Marthe H. R., et al.
Publicado: (2018)

Lipid peroxidation is essential for α‐synuclein‐induced cell death
por: Angelova, Plamena R., et al.
Publicado: (2015)

An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation
por: Natalwala, Ammar, et al.
Publicado: (2022)

α-Synuclein–Confocal Nanoscanning (ASYN-CONA), a Bead-Based Assay for Detecting Early-Stage α-Synuclein Aggregation
por: Pérez-Pi, Irene, et al.
Publicado: (2019)

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

Author Correction: Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
por: Choi, Minee L., et al.
Publicado: (2022)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
por: Deas, Emma, et al.
Publicado: (2016)

In vivo(18)F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation
por: Morley, Victoria, et al.
Publicado: (2023)

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
por: Virdi, Gurvir S., et al.
Publicado: (2022)

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
por: Reeve, A K, et al.
Publicado: (2015)

Cryopreservation of Human Midbrain Dopaminergic Neural Progenitor Cells Poised for Neuronal Differentiation
por: Drummond, Nicola J., et al.
Publicado: (2020)

Lipid‐induced polymorphic amyloid fibril formation by α‐synuclein
por: Singh, Bhanu P., et al.
Publicado: (2023)

Engineering synucleinopathy‐resistant human dopaminergic neurons by CRISPR‐mediated deletion of the SNCA gene
por: Chen, Yixi, et al.
Publicado: (2018)

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
por: Iljina, Marija, et al.
Publicado: (2016)

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
por: Hughes, Craig D., et al.
Publicado: (2018)

Carbon monoxide neurotoxicity is triggered by oxidative stress induced by ROS production from three distinct cellular sources
por: Angelova, Plamena R., et al.
Publicado: (2023)

Polyhydroxybutyrate Targets Mammalian Mitochondria and Increases Permeability of Plasmalemmal and Mitochondrial Membranes
por: Elustondo, Pia A., et al.
Publicado: (2013)

Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry
por: Jeacock, Kiani, et al.
Publicado: (2023)

Inorganic polyphosphate is produced and hydrolyzed in F(0)F(1)-ATP synthase of mammalian mitochondria
por: Baev, Artyom Y., et al.
Publicado: (2020)

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
por: Iljina, Marija, et al.
Publicado: (2017)

Optical Structural Analysis of Individual α‐Synuclein Oligomers
por: Varela, Juan A., et al.
Publicado: (2018)

The regulatory role of GABA(A) receptor in Actinia equina nervous system and the possible effect of global ocean acidification
por: Snigirov, Sergii, et al.
Publicado: (2021)

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale
por: Lee, Ji-Eun, et al.
Publicado: (2018)

Spontaneously opening GABA(A) receptors play a significant role in neuronal signal filtering and integration
por: O’Neill, Nathanael, et al.
Publicado: (2018)

The Functional Role of Spontaneously Opening GABA(A) Receptors in Neural Transmission
por: O’Neill, Nathanael, et al.
Publicado: (2019)

Signal transduction in astrocytes: Localization and release of inorganic polyphosphate
por: Angelova, Plamena R., et al.
Publicado: (2018)

RT001 in Progressive Supranuclear Palsy—Clinical and In-Vitro Observations
por: Angelova, Plamena R., et al.
Publicado: (2021)

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation
por: Wang, Yu, et al.
Publicado: (2019)

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
por: Devine, Michael J., et al.
Publicado: (2011)

Multi-target action of β-alanine protects cerebellar tissue from ischemic damage
por: Kopach, Olga, et al.
Publicado: (2022)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase
por: Kovac, Stjepana, et al.
Publicado: (2015)

Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons
por: Kamynina, Anna, et al.
Publicado: (2021)

Hyperammonaemia induces mitochondrial dysfunction and neuronal cell death
por: Angelova, Plamena R., et al.
Publicado: (2022)

Central Synapses Release a Resource-Efficient Amount of Glutamate
por: Savtchenko, Leonid P., et al.
Publicado: (2012)

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation
por: Angelova, Plamena R., et al.
Publicado: (2017)

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
por: Tosatto, Laura, et al.
Publicado: (2015)

A Universal Vector for High-Efficiency Multi-Fragment Recombineering of BACs and Knock-In Constructs
por: Dolt, Karamjit Singh, et al.
Publicado: (2013)

Hemichannel-mediated release of lactate
por: Karagiannis, Anastassios, et al.
Publicado: (2015)

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease
por: Dolgacheva, Ludmila P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ajg53mkde0n3100kt4ulv4n3pm