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Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia
Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Ri...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492521/ https://www.ncbi.nlm.nih.gov/pubmed/32983140 http://dx.doi.org/10.3389/fimmu.2020.01995 |