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Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia

Most patients with chronic lymphocytic leukemia (CLL) exhibit an indolent disease course and unresponsive B cell receptors (BCRs) exemplified by an anergic phenotype of their leukemic cells. In up to 5% of patients, CLL transforms from an indolent subtype to an aggressive form of B cell lymphoma (Ri...

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Detalles Bibliográficos
Autores principales:	Märklin, Melanie, Fuchs, Alexander R., Tandler, Claudia, Heitmann, Jonas S., Salih, Helmut R., Kauer, Joseph, Quintanilla-Martinez, Leticia, Wirths, Stefan, Kopp, Hans-Georg, Müller, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492521/ https://www.ncbi.nlm.nih.gov/pubmed/32983140 http://dx.doi.org/10.3389/fimmu.2020.01995

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