The Development of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disorders

The expanded GGGGCC hexanucleotide repeat in the non-coding region of the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). There are three main disease mechanisms: loss of function of C9ORF72 protein, gain of function from the ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Qijie, Jiao, Bin, Shen, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492664/
https://www.ncbi.nlm.nih.gov/pubmed/32983232
http://dx.doi.org/10.3389/fgene.2020.562758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492664/
https://www.ncbi.nlm.nih.gov/pubmed/32983232
http://dx.doi.org/10.3389/fgene.2020.562758

Ejemplares similares