Naphthalene diimide bis-guanidinio-carbonyl-pyrrole as a pH-switchable threading DNA intercalator

A novel naphthalene diimde analogue (NDI) equipped at the imide positions with two guanidinio-carbonyl-pyrrole (GCP) pendant arms interacted significantly stronger with ds-DNA at pH 5 than at pH 7, due to reversible protonation of the GCP arms. This was consequence of a pH-switchable threading inter...

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Detalles Bibliográficos
Autores principales: Jana, Poulami, Šupljika, Filip, Schmuck, Carsten, Piantanida, Ivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492691/
https://www.ncbi.nlm.nih.gov/pubmed/32983268
http://dx.doi.org/10.3762/bjoc.16.185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492691/
https://www.ncbi.nlm.nih.gov/pubmed/32983268
http://dx.doi.org/10.3762/bjoc.16.185

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