Identifying Transcription Factor Combinations to Modulate Circadian Rhythms by Leveraging Virtual Knockouts on Transcription Networks

The mammalian circadian systems consist of indigenous, self-sustained 24-h rhythm generators. They comprise many genes, molecules, and regulators. To decode their systematic controls, a robust computational approach was employed. It integrates transcription-factor-occupancy and time-series gene-expr...

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Detalles Bibliográficos
Autores principales: Chowdhury, Debajyoti, Wang, Chao, Lu, Aiping, Zhu, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492989/
https://www.ncbi.nlm.nih.gov/pubmed/32920484
http://dx.doi.org/10.1016/j.isci.2020.101490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492989/
https://www.ncbi.nlm.nih.gov/pubmed/32920484
http://dx.doi.org/10.1016/j.isci.2020.101490

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