Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3.1 mRNA, causing transformation of human cells in vitro....

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Detalles Bibliográficos
Autores principales: Chen, Danqi, Chen, Qiao Yi, Wang, Zhenjia, Zhu, Yusha, Kluz, Thomas, Tan, Wuwei, Li, Jinquan, Wu, Feng, Fang, Lei, Zhang, Xiaoru, He, Rongquan, Shen, Steven, Sun, Hong, Zang, Chongzhi, Jin, Chunyuan, Costa, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492993/
https://www.ncbi.nlm.nih.gov/pubmed/32920490
http://dx.doi.org/10.1016/j.isci.2020.101518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492993/
https://www.ncbi.nlm.nih.gov/pubmed/32920490
http://dx.doi.org/10.1016/j.isci.2020.101518

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