Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma

BACKGROUND: Ataxia-telangiectasia and Rad3 related protein kinase (ATR) is an essential regulator of the DNA damage response in various cancers; however, its expression and roles in osteosarcoma are unclear. We therefore chose to evaluate the significance and mechanism of ATR in metastatic osteosarc...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyang, Dean, Dylan C., Cote, Gregory M., Zou, Lee, Hornicek, Francis J., Yu, Shengji, Duan, Zhenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493280/
https://www.ncbi.nlm.nih.gov/pubmed/32973933
http://dx.doi.org/10.1177/1758835920956900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493280/
https://www.ncbi.nlm.nih.gov/pubmed/32973933
http://dx.doi.org/10.1177/1758835920956900

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