Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing

Axonal degeneration is a key and early pathological feature in traumatic and neurodegenerative disorders of the CNS. Following a focal lesion to axons, extended axonal disintegration by acute axonal degeneration (AAD) occurs within several hours. During AAD, the accumulation of autophagic proteins i...

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Detalles Bibliográficos
Autores principales: Vahsen, Björn Friedhelm, Ribas, Vinicius Toledo, Sundermeyer, Jonas, Boecker, Alexander, Dambeck, Vivian, Lenz, Christof, Shomroni, Orr, Caldi Gomes, Lucas, Tatenhorst, Lars, Barski, Elisabeth, Roser, Anna-Elisa, Michel, Uwe, Urlaub, Henning, Salinas, Gabriela, Bähr, Mathias, Koch, Jan Christoph, Lingor, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493890/
https://www.ncbi.nlm.nih.gov/pubmed/32341448
http://dx.doi.org/10.1038/s41418-020-0543-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493890/
https://www.ncbi.nlm.nih.gov/pubmed/32341448
http://dx.doi.org/10.1038/s41418-020-0543-y

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