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Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here we propose a self-delivering one-component new-chemical-entity nanomedicine (ONN) strategy to improve cancer therapy through incorporation of the self-as...

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Detalles Bibliográficos
Autores principales: Ma, Zhao, Li, Jin, Lin, Kai, Ramachandran, Mythili, Zhang, Dalin, Showalter, Megan, De Souza, Cristabelle, Lindstrom, Aaron, Solano, Lucas N., Jia, Bei, Urayama, Shiro, Duan, Yuyou, Fiehn, Oliver, Lin, Tzu-yin, Li, Minyong, Li, Yuanpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493904/
https://www.ncbi.nlm.nih.gov/pubmed/32934241
http://dx.doi.org/10.1038/s41467-020-18399-4