Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer

HDAC inhibitors are efficacious for treating lymphoma, but display limited efficacy in treating solid tumors. Here, we investigated the relationship between HDAC inhibitor resistance and the tumor immune environment in colorectal cancer. Our data indicated that among the investigated immune factors,...

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Detalles Bibliográficos
Autores principales: Li, Yuxin, Liu, Yao, Zhao, Na, Yang, Xiaojun, Li, Yaqing, Zhai, Fangzheng, Zang, Xingxing, Cui, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493945/
https://www.ncbi.nlm.nih.gov/pubmed/32934224
http://dx.doi.org/10.1038/s41419-020-02968-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493945/
https://www.ncbi.nlm.nih.gov/pubmed/32934224
http://dx.doi.org/10.1038/s41419-020-02968-y

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