Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein

Here we report bisphenol derivatives of fluorene (BDFs) as a new type of chemical probes targeting a histone-like HU protein, a global regulator of bacterial nucleoids, via its dimerization interface perturbation. BDFs were identified by virtual screening and molecular docking that targeted the core...

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Detalles Bibliográficos
Autores principales: Agapova, Yuliya K., Altukhov, Dmitry A., Timofeev, Vladimir I., Stroylov, Victor S., Mityanov, Vitaly S., Korzhenevskiy, Dmitry A., Vlaskina, Anna V., Smirnova, Eugenia V., Bocharov, Eduard V., Rakitina, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493962/
https://www.ncbi.nlm.nih.gov/pubmed/32934267
http://dx.doi.org/10.1038/s41598-020-72113-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493962/
https://www.ncbi.nlm.nih.gov/pubmed/32934267
http://dx.doi.org/10.1038/s41598-020-72113-4

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