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Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein

Here we report bisphenol derivatives of fluorene (BDFs) as a new type of chemical probes targeting a histone-like HU protein, a global regulator of bacterial nucleoids, via its dimerization interface perturbation. BDFs were identified by virtual screening and molecular docking that targeted the core...

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Detalles Bibliográficos
Autores principales:	Agapova, Yuliya K., Altukhov, Dmitry A., Timofeev, Vladimir I., Stroylov, Victor S., Mityanov, Vitaly S., Korzhenevskiy, Dmitry A., Vlaskina, Anna V., Smirnova, Eugenia V., Bocharov, Eduard V., Rakitina, Tatiana V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493962/ https://www.ncbi.nlm.nih.gov/pubmed/32934267 http://dx.doi.org/10.1038/s41598-020-72113-4

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