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Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
BACKGROUND: The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining the topolo...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493976/ https://www.ncbi.nlm.nih.gov/pubmed/32933554 http://dx.doi.org/10.1186/s13059-020-02152-7 |