Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation

BACKGROUND: The three-dimensional genome organization is critical for gene regulation and can malfunction in diseases like cancer. As a key regulator of genome organization, CCCTC-binding factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintaining the topolo...

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Detalles Bibliográficos
Autores principales: Fang, Celestia, Wang, Zhenjia, Han, Cuijuan, Safgren, Stephanie L., Helmin, Kathryn A., Adelman, Emmalee R., Serafin, Valentina, Basso, Giuseppe, Eagen, Kyle P., Gaspar-Maia, Alexandre, Figueroa, Maria E., Singer, Benjamin D., Ratan, Aakrosh, Ntziachristos, Panagiotis, Zang, Chongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493976/
https://www.ncbi.nlm.nih.gov/pubmed/32933554
http://dx.doi.org/10.1186/s13059-020-02152-7

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