A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling

The canonical mammalian Hippo pathway contains a core kinase signaling cascade requiring upstream MST to form a stable complex with SAV1 in order to phosphorylate the downstream LATS/MOB complex. Though SAV1 dimerization is essential for the trans-activation of MST, the molecular mechanism underlyin...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Zhijie, Xie, Ruiling, Guan, Kunliang, Zhang, Mingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494017/
https://www.ncbi.nlm.nih.gov/pubmed/32905778
http://dx.doi.org/10.1016/j.celrep.2020.108118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494017/
https://www.ncbi.nlm.nih.gov/pubmed/32905778
http://dx.doi.org/10.1016/j.celrep.2020.108118

Ejemplares similares