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A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling
The canonical mammalian Hippo pathway contains a core kinase signaling cascade requiring upstream MST to form a stable complex with SAV1 in order to phosphorylate the downstream LATS/MOB complex. Though SAV1 dimerization is essential for the trans-activation of MST, the molecular mechanism underlyin...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494017/ https://www.ncbi.nlm.nih.gov/pubmed/32905778 http://dx.doi.org/10.1016/j.celrep.2020.108118 |