FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity

Defective mitophagy is causally linked to obesity complications. Here, we identified an interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor subunit of human SCF (SKP1/cullin/F-box protein) ubiquitin ligase complex FBXL2 as a gatekeeper for mitochondrial Ca(2+) homeo...

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Detalles Bibliográficos
Autores principales: Ren, Jun, Sun, Mingming, Zhou, Hao, Ajoolabady, Amir, Zhou, Yuan, Tao, Jun, Sowers, James R., Zhang, Yingmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494344/
https://www.ncbi.nlm.nih.gov/pubmed/32938669
http://dx.doi.org/10.1126/sciadv.abc8561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494344/
https://www.ncbi.nlm.nih.gov/pubmed/32938669
http://dx.doi.org/10.1126/sciadv.abc8561

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